Preparation and characterization of electrospun polyacrylonitrile fiber mats containing Garcinia mangostana

Garcinia mangostana-loaded electrospun polyacrylonitrile (PAN) fiber mats with antibacterial and anti-tuberculosis properties were fabricated from PAN solution containing G. mangostana extract in dimethylformamide. 10% PAN solution was mixed with G. mangostana in amounts of 10, 15, 20, and 30 wt% based on the weight of PAN powder used in the experiment. The PAN solutions were processed using the electrospinning process. Both untreated (neat) and G. mangostana-loaded PAN fibers were smooth in appearance, and the average diameter of samples was similar to 215 and similar to 245 nm, respectively. Morphologies, release characteristics, antimicrobial efficiencies against Staphylococcus aureus, Methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus pyogenes, and anti-tuberculosis properties of the neat electrospun and 10-30% G. mangostana-loaded e-spun fiber mats were investigated. In vitro release studies of G. mangostana from e-spun PAN fiber mats were determined using the total immersion method in acetate buffer and phosphate buffer solutions containing Tween 80 and methanol. The cumulative released amount of G. mangostana from the samples proportionally increased with the increase of G. mangostana incorporated in the spinning solutions. This study demonstrated a convenient procedure with the potential to develop the antimicrobial and anti-tuberculosis properties of electrospun fibrous membranes containing G. mangostana, which are beneficial in filtration applications for respirators, face masks, and air-conditioning filters.

用含有二化甲酰胺中的芒果叶提取物的PAN溶液制备了藤黄负载的静电纺聚丙烯腈（PAN）纤维毡。基于实验中使用的PAN粉末的重量，将10％PAN溶液与Mangostana混合在一起，其用量分别为10、15、20和30 wt％。使用静电纺丝工艺处理PAN溶液。未经处理的（纯净的）和负载PAN纤维的外观均光滑，样品的平均直径分别类似于215 nm和245 nm。报告了金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）、表皮葡萄球菌、无乳链球菌、化脓性链球菌的抗微生物作用以及纯净的电纺丝和10-30％的G. mangos的抗结核特性。使用总浸没法在含有Tween 80和甲醇的醋酸盐缓冲液和磷酸盐缓冲液中进行全浸法测定电纺PAN纤维毡中释放的研究。随着旋转溶液中所含的增加，从样品中累积的芒果的释放量成比例地增加。这项研究证明了，开发含有抗菌抗结核特性的电纺纤维膜的的潜力。这对于呼吸器，口罩和空调过滤器的过滤应用是有益的。

Published: 2018

Journal ：POLYMER BULLETIN

Impact Factor：1.859

Paper link: https://link.springer.com/article/10.1007/s00289-017-2087-y